EFFECTS OF ELECTROCONVULSIVE SHOCK ON MOUSE-KILLING BEHAVIOR (MURICIDE) IN OLFACTORY BULBECTOMIZED RATS
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The effect of a selective phosphodiesterase inhibitor, rolipram, on muricide in olfactory bulbectomized rats.
In order to evaluate the potential usefulness of the drug as an antidepressant, acute and chronic effects of rolipram, a selective inhibitor of Ca2+- and calmodulin-independent cyclic AMP phosphodiesterase were investigated on muricide in olfactory bulbectomized (OB) rats. Upon single administration to OB rats, rolipram at a dosage of 1 mg/kg body weight suppressed the muricide for 2 hr after i...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1981
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)52876-1